Application of Escherichia coli-Derived Recombinant Human Bone Morphogenic Protein-2 to Unstable Spinal Fractures
نویسندگان
چکیده
(1) Background: Recently, Escherichia coli-derived recombinant human bone morphogenetic protein-2 (E. rhBMP-2) has been increasingly applied to different types of spinal surgeries and reported achieve successful fusion. This pilot study aimed evaluate the clinical efficacy safety rhBMP-2 in patients undergoing posterior instrumented fusions for unstable fractures. (2) Methods: included ten consecutive surgery using E. with more than one year follow-up. Radiologic outcomes were compared, including average fracture healing period, local kyphosis correction, between preoperative last (3) Results: The time radiographic union was 99.9 ± 45.4 (62–192) days, an use 5.2 3.9 months anabolic agents. parameters such as anterior vertebral height wedge angle significantly corrected postoperatively at Clinical other leg pain improved after surgery. In addition, four neurologic deficits showed status. (4) Conclusions: Combined agents, applying fractured body could be effective surgical treatment Further trials are needed validate this result.
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ژورنال
عنوان ژورنال: Bioengineering
سال: 2023
ISSN: ['2306-5354']
DOI: https://doi.org/10.3390/bioengineering10101114